Alan finds out some surprising information about Judith's sex life when he decides to go on a date with one of her friends.

With his friends knowing how sour he acts when sick—and avoiding him as a result—Sheldon is nursed for by Penny, who hasn't a clue what she's in for.

Rose returns from England, and plays nurse for an ill Charlie. Alan feels Jake pulling away from him.

Leonard and Sheldon each lie to avoid hearing Penny sing in a production of Rent. However, Sheldon's lie becomes a bit too complicated for its own good.

Uncle Earl comes to visit and expects Miley to help him become a rock star.

When Alan finds himself wanting to break up with a woman, Charlie offers his expertise.

When they're invited to present at a physics conference, Sheldon's reluctance to share the credit leads to a tiff between he and Leonard, and Penny's intervention only exacerbates the situation.